SCHEMBL8924910

SCHEMBL8924910

COc1ccc(-n2c(C)ccc2C)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.53
ATM Q13315 1/20 0.53
MAPT P10636 6/20 0.53
ALDH1A1 P00352 5/20 0.53
CA12 O43570 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
APEX1 P27695 2/20 0.52
NR4A1 P22736 1/20 0.52
KDM4E B2RXH2 3/20 0.50
LMNA P02545 3/20 0.50
ACHE P22303 1/20 0.50
ALOX15 P16050 1/20 0.50
CYP1A2 P05177 1/20 0.48
CYP2C9 P11712 1/20 0.48
GSK3A P49840 1/20 0.47
GSK3B P49841 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31125245 0.87 MAPT (0.48) NPC1ATMMAPTALDH1A1CA12
SCHEMBL6285757 0.77 MAPT (0.51) MAPTALDH1A1CA1CA2KDM4E
SCHEMBL9389184 0.76 GSK3A (0.61) NPC1ATMMAPTALDH1A1CA12
SCHEMBL6279769 0.76 HTT (0.50) MAPTALDH1A1CA1CA2KDM4E
SCHEMBL31554576 0.76 MYC (0.50) NPC1ATMMAPTALDH1A1APEX1
SCHEMBL5005240 0.76 NR4A1 (0.61) NPC1MAPTALDH1A1APEX1NR4A1
SCHEMBL6241021 0.76 HPGD (0.56) ATMMAPTALDH1A1CA12CA1
SCHEMBL16719288 0.76 NOTUM (0.57) NPC1MAPTALDH1A1CA1CA2
SCHEMBL17735499 0.76 NPC1 (0.62) NPC1ATMMAPTALDH1A1CA12
SCHEMBL24992152 0.74 CA12 (0.50) NPC1ATMMAPTALDH1A1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113105381-A Preparation method of biomass-based 2, 5-dimethyl-N-substituted pyrrole derivative 贵州大学 2021-07-13 CN claimed
CN-119569634-A Process for the preparation of N-substituted pyrrole compounds 中国石油化工股份有限公司 2025-03-07 CN disclosed
CN-119570046-A Modified metal organic framework material and preparation method and application thereof 中国石油化工股份有限公司 2025-03-07 CN disclosed
CN-113501776-B Near infrared luminous free radical cation compound and preparation and application thereof 华南理工大学 2023-08-22 CN disclosed
CN-113105381-A Preparation method of biomass-based 2, 5-dimethyl-N-substituted pyrrole derivative 贵州大学 2021-07-13 CN disclosed
CN-111574424-B Method for preparing N-aryl pyrrole compound 南京林业大学 2021-07-06 CN disclosed
CN-111574424-A Method for preparing N-aryl pyrrole compound 南京林业大学 2020-08-25 CN disclosed
US-20200093135-A1 SYSTEMS FOR PEST ELIMINATION, SUPPRESSION OR CONTROL EMEKATECH LLC (US) 2020-03-26 US disclosed
US-20170055532-A1 SYSTEMS FOR PEST ELIMINATION, SUPPRESSION OR CONTROL Emekatech, LLC. (US) 2017-03-02 US disclosed
EP-3110253-A1 SYSTEMS FOR PEST ELIMINATION, SUPPRESSION OR CONTROL Emekatech, LLC (US) 2017-01-04 EP disclosed
WO-2015127311-A1 SYSTEMS FOR PEST ELIMINATION, SUPPRESSION OR CONTROL EMEKATECH, LLC (US) 2015-08-27 WO disclosed
WO-2009148004-A1 NOVEL COMPOUND AND PHARMACEUTICAL APPLICATION OF SAME 株式会社 三和化学研究所 (JP) 2009-12-10 WO disclosed
US-5676884-A Nonlinear optical materials containing polar disulfone-functionalized molecules MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-10-14 US disclosed
US-5578251-A NONLINEAR-OPTICAL RESPONSE; ALKYLATION MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-11-26 US disclosed
US-5360582-A Compositions with polymers for light sensitive elements MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-11-01 US disclosed
EP-0594697-A1 NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-05-04 EP disclosed
WO-1993002383-A1 NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-02-04 WO disclosed