SCHEMBL8924914

SCHEMBL8924914

COc1ccc(Cn2c(C)ccc2C)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 1.00
ALDH1A1 P00352 4/20 1.00
MAPT P10636 3/20 1.00
ALOX15 P16050 1/20 1.00
CMA1 P23946 1/20 0.55
GAA P10253 3/20 0.53
GFER P55789 1/20 0.53
SMN1; SMN2 Q16637 4/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
MEN1 O00255 2/20 0.52
POLB P06746 2/20 0.52
KMT2A Q03164 2/20 0.52
GSK3A P49840 1/20 0.52
GSK3B P49841 1/20 0.52
USP2 O75604 1/20 0.52
THRB P10828 1/20 0.52
NR4A1 P22736 1/20 0.52
APEX1 P27695 1/20 0.52
APOBEC3A P31941 1/20 0.52
RECQL P46063 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31560451 0.84 MAPT (0.72) KDM4EALDH1A1MAPTALOX15CMA1
SCHEMBL6287671 0.78 KDM4E (0.63) KDM4EALDH1A1MAPTALOX15GAA
SCHEMBL19048416 0.77 ALDH1A1 (0.62) KDM4EALDH1A1MAPTALOX15CMA1
SCHEMBL4769071 0.76 ALDH1A1 (0.60) KDM4EALDH1A1MAPTALOX15CMA1
SCHEMBL23063309 0.75 KDM4E (0.59) KDM4EALDH1A1MAPTALOX15CMA1
SCHEMBL21333131 0.74 ALDH1A1 (0.59) KDM4EALDH1A1MAPTALOX15GAA
SCHEMBL17675021 0.73 ALDH1A1 (0.57) KDM4EALDH1A1MAPTALOX15CMA1
SCHEMBL12301203 0.73 MAPT (0.58) KDM4EALDH1A1MAPTALOX15CMA1
SCHEMBL18356958 0.73 P2RX4 (0.82) KDM4EALDH1A1MAPTALOX15GAA
SCHEMBL6521231 0.73 KDM4E (0.59) KDM4EALDH1A1MAPTALOX15GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200093135-A1 SYSTEMS FOR PEST ELIMINATION, SUPPRESSION OR CONTROL EMEKATECH LLC (US) 2020-03-26 US disclosed
US-20170055532-A1 SYSTEMS FOR PEST ELIMINATION, SUPPRESSION OR CONTROL Emekatech, LLC. (US) 2017-03-02 US disclosed
EP-3110253-A1 SYSTEMS FOR PEST ELIMINATION, SUPPRESSION OR CONTROL Emekatech, LLC (US) 2017-01-04 EP disclosed
WO-2015127311-A1 SYSTEMS FOR PEST ELIMINATION, SUPPRESSION OR CONTROL EMEKATECH, LLC (US) 2015-08-27 WO disclosed
US-5676884-A Nonlinear optical materials containing polar disulfone-functionalized molecules MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-10-14 US disclosed
US-5578251-A NONLINEAR-OPTICAL RESPONSE; ALKYLATION MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-11-26 US disclosed
US-5360582-A Compositions with polymers for light sensitive elements MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-11-01 US disclosed
WO-1993002383-A1 NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-02-04 WO disclosed