Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAP2 | P11137 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532104 | 0.84 | KDM4E (0.65) | DAOMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL8925766 | 0.79 | DAO (0.53) | DAORAB9ANPC1CLK2GSK3A | |
| SCHEMBL8924872 | 0.79 | DAO (0.65) | DAOKDM4ECLK2GSK3BCLK4 | |
| SCHEMBL4552979 | 0.78 | KDM4E (0.47) | ELANEMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL11187166 | 0.77 | DAO (0.57) | DAOMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL8925407 | 0.77 | CA1 (0.53) | DAOMAP2GSK3BGCGRMAPK14 | |
| SCHEMBL4553365 | 0.76 | MAPT (0.50) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL8784457 | 0.74 | CYP1A2 (0.58) | MEN1KMT2AKDM4EMAP2TSHR | |
| SCHEMBL8924998 | 0.74 | MAP2 (0.54) | ELANEMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3745439 | 0.74 | DAO (0.43) | DAOAMY1AMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | claimed |
| US-5614532-A | NERVOUS SYSTEM DISORDERS USING N-METHYLASPARTATE ANTAGONIST | MERCK, SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |
| EP-0620812-A1 | QUINOLONE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |