Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8925985 | 1.00 | ADRA2C (0.66) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B | |
| SCHEMBL1698274 | 0.86 | ADRA2C (0.64) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B | |
| SCHEMBL21254322 | 0.85 | SLC6A4 (0.55) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B | |
| SCHEMBL21254631 | 0.85 | HTR2A (0.58) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B | |
| SCHEMBL21254330 | 0.85 | SLC6A4 (0.55) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B | |
| SCHEMBL8926000 | 0.85 | HTR2A (0.55) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B | |
| SCHEMBL8926009 | 0.85 | HTR2A (0.55) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B | |
| SCHEMBL31712324 | 0.85 | HTR2A (0.55) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B | |
| SCHEMBL2924439 | 0.84 | HTR2A (0.65) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B | |
| SCHEMBL2925939 | 0.84 | HTR2A (0.65) | ADRA2CHTR2ASLC6A4SLC6A2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614518-A | Morpholine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |