SCHEMBL8926096

SCHEMBL8926096

CCC(Oc1cc2c(CC(N)=O)c(Br)n(Cc3ccccc3)c2cc1Cl)C(=O)O

nearest known ligand 0.74

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 20/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8926546 0.92 PLA2G2A (0.70) PLA2G2A
SCHEMBL8926507 0.86 PLA2G2A (0.74) PLA2G2A
SCHEMBL7962093 0.80 PLA2G2A (1.00) PLA2G2A
SCHEMBL7962107 0.79 PLA2G2A (0.82) PLA2G2A
SCHEMBL8926159 0.78 PLA2G2A (0.71) PLA2G2A
SCHEMBL8924518 0.77 PLA2G2A (0.74) PLA2G2A
SCHEMBL8926095 0.77 PLA2G2A (0.77) PLA2G2A
SCHEMBL8924924 0.75 PLA2G2A (0.74) PLA2G2A
SCHEMBL8924460 0.75 PLA2G2A (0.74) PLA2G2A
SCHEMBL8926543 0.75 PLA2G2A (0.61) PLA2G2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5684034-A INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE ELI LILLY AND COMPANY (US) 1997-11-04 US disclosed