Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.32 |
| ▸ | ALB | P02768 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.32 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17372493 | 0.81 | PDE3A (0.35) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL2511488 | 0.80 | FGFR1 (0.36) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL9177313 | 0.80 | FGFR1 (0.36) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL8743037 | 0.80 | FGFR1 (0.36) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL8743030 | 0.80 | FGFR1 (0.36) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL8927492 | 0.79 | ALB (0.35) | ALB | |
| Hydrochloric Acid SCHEMBL31390165 | 0.79 | FGFR1 (0.36) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| Hydrochloric Acid SCHEMBL22411438 | 0.79 | FGFR1 (0.36) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL8927153 | 0.78 | — | — | |
| SCHEMBL8927502 | 0.78 | ADORA2A (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5644043-A | ANTITUMOR, ANTICANCER, TREATMENT OF HERPES | ELI LILLY AND COMPANY (US) | 1997-07-01 | — | — | US | disclosed |
| US-5574021-A | LEUKEMIA | ELI LILLY AND COMPANY (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0329348-B1 | 2',3'-Dideoxy-2',2'-difluoronucleosides | LILLY CO ELI (US) | 1995-07-12 | — | — | EP | disclosed |
| EP-0329348-A2 | 2',3'-Dideoxy-2',2'-difluoronucleosides | ELI LILLY AND COMPANY (US) | 1989-08-23 | — | — | EP | disclosed |