Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 9/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM6A | O15550 | 1/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM4B | O94953 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8926557 | 1.00 | KDM4E (0.43) | KDM4EPDE4AKCNH2TOP2ATOP2B | |
| SCHEMBL7960307 | 0.83 | KDM4E (0.55) | KDM4EPDE4AKCNH2TOP2ATOP2B | |
| SCHEMBL7951788 | 0.81 | KDM4E (0.60) | KDM4EPDE4AKCNH2TOP2ATOP2B | |
| SCHEMBL7946345 | 0.81 | KDM4E (0.63) | KDM4EPDE4AKCNH2TOP2ATOP2B | |
| SCHEMBL7953294 | 0.80 | KDM4E (0.65) | KDM4EPDE4AKCNH2TOP2ATOP2B | |
| SCHEMBL7963744 | 0.80 | KDM4E (0.46) | KDM4EPDE4AKCNH2TOP2ATOP2B | |
| SCHEMBL2082203 | 0.79 | KDM4E (0.64) | KDM4ECYP3A4 | |
| SCHEMBL2082206 | 0.79 | KDM4E (0.64) | KDM4ECYP3A4 | |
| SCHEMBL27477707 | 0.79 | KDM4E (0.64) | KDM4ECYP3A4 | |
| SCHEMBL5653364 | 0.79 | KDM4E (0.44) | KDM4ETOP2ATOP2BCYP3A4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5621105-A | REACTING HALO-SUBSTITUTED QUINOLONECARBOXYLIC ACID OR NAPHTHYRIDONECARBOXYLIC ACID WITH 1-AMINOMETHYL-2-OXA-7-AZABICYCLO/3.3.0/OCTANE | BAYER AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |