Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TOP2A | P11388 | 4/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM6A | O15550 | 1/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM4B | O94953 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963124 | 0.93 | KDM4E (0.51) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7963122 | 0.93 | KDM4E (0.51) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7960307 | 0.90 | KDM4E (0.55) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7951788 | 0.85 | KDM4E (0.60) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7946345 | 0.85 | KDM4E (0.63) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7953294 | 0.84 | KDM4E (0.65) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7961896 | 0.83 | HTR3A (0.43) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7955375 | 0.82 | KDM4E (0.50) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7946466 | 0.82 | KDM4E (0.47) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7951798 | 0.82 | KDM4E (0.47) | KDM4ETOP2ATOP2BPIK3CGGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |