Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21811769 | 0.82 | TSHR (0.43) | TSHRALDH1A1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL13433733 | 0.79 | TP53 (0.36) | TSHRTDP1 | |
| SCHEMBL21811766 | 0.78 | TSHR (0.41) | TSHRALDH1A1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7675814 | 0.78 | TSHR (0.48) | TSHRALDH1A1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL27452776 | 0.78 | TSHR (0.48) | TSHRALDH1A1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9157102 | 0.78 | TSHR (0.48) | TSHRALDH1A1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL4253576 | 0.78 | TSHR (0.48) | TSHRALDH1A1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL27926178 | 0.78 | TSHR (0.48) | TSHRALDH1A1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9722940 | 0.78 | TP53 (0.30) | TSHRTDP1 | |
| SCHEMBL30145011 | 0.78 | TSHR (0.52) | TSHRALDH1A1TDP1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663365-A | Process for the preparation of pyrazolones | JAPAN HYDRAZINE CO., LTD. (JP) | 1997-09-02 | — | — | US | disclosed |