Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.31 |
| ▸ | CD44 | P16070 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3424465 | 0.87 | AHR (0.44) | AHRCYP2A6CYP1A2TSHRACHE | |
| SCHEMBL10506604 | 0.87 | — | — | |
| SCHEMBL3423393 | 0.85 | AHR (0.43) | AHRCYP2A6CYP1A2TSHRACHE | |
| SCHEMBL13113555 | 0.81 | AHR (0.56) | AHRCYP2A6CYP1A2TSHRACHE | |
| Chloroform SCHEMBL9781527 | 0.79 | AHR (0.43) | AHRCYP2A6CYP1A2TSHRACHE | |
| SCHEMBL25137467 | 0.76 | HPGD (0.33) | AHRCYP1A2TSHRACHEALDH1A1 | |
| SCHEMBL25137434 | 0.74 | ALDH1A1 (0.34) | AHRCYP2A6CYP1A2ALDH1A1CA1 | |
| SCHEMBL15332947 | 0.73 | AHR (0.43) | AHRTSHRACHE | |
| SCHEMBL5588609 | 0.73 | ALDH1A1 (0.43) | AHRCYP1A2TSHRALDH1A1MAP3K14 | |
| SCHEMBL15763903 | 0.73 | HPGD (0.38) | ALDH1A1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210115058-A1 | SPIROCYCLIC COMPOUNDS | RECURIUM IP HOLDINGS, LLC | 2021-04-22 | — | — | US | claimed |
| US-20200207776-A1 | SPIROCYCLIC COMPOUNDS | Zeno Royalties & Milestones, LLC | 2020-07-02 | — | — | US | claimed |
| EP-3523306-A1 | SPIROCYCLIC COMPOUNDS | Zeno Royalties & Milestones, LLC (US) | 2019-08-14 | — | — | EP | claimed |
| WO-2018067512-A1 | SPIROCYCLIC COMPOUNDS | KALYRA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | claimed |
| US-5691363-A | CONTROLLING PHYTOPATHOGENIC FUNGI; APPLYING TO PLANT BEFORE PLANTING | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1997-11-25 | — | — | US | claimed |
| US-20210115058-A1 | SPIROCYCLIC COMPOUNDS | RECURIUM IP HOLDINGS, LLC | 2021-04-22 | — | — | US | disclosed |
| US-10934304-B2 | Spirocyclic compounds | RECURIUM IP HOLDINGS, LLC (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200207776-A1 | SPIROCYCLIC COMPOUNDS | Zeno Royalties & Milestones, LLC | 2020-07-02 | — | — | US | disclosed |
| EP-3523306-A1 | SPIROCYCLIC COMPOUNDS | Zeno Royalties & Milestones, LLC (US) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018067512-A1 | SPIROCYCLIC COMPOUNDS | KALYRA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |
| US-5691363-A | CONTROLLING PHYTOPATHOGENIC FUNGI; APPLYING TO PLANT BEFORE PLANTING | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1997-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115058-A1 | SPIROCYCLIC COMPOUNDS | PKD1, AR, PKD2 | AHR 1410/4885CYP2A6 583/4885CYP1A2 1217/4885 |
| US-20200207776-A1 | SPIROCYCLIC COMPOUNDS | PKD1, AR, PKD2 | AHR 1410/4885CYP2A6 583/4885CYP1A2 1217/4885 |
| US-10934304-B2 | Spirocyclic compounds | PKD1, AR, PKD2 | AHR 1410/4885CYP2A6 583/4885CYP1A2 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.