Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.67 |
| ▸ | ALPI | P09923 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.67 |
| ▸ | XIAP | P98170 | 1/20 | 0.67 |
| ▸ | ANPEP | P15144 | 2/20 | 0.59 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.59 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.59 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.58 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.58 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL23152419 | 1.00 | SLC7A5 (0.67) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL3401561 | 1.00 | SLC7A5 (0.67) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL3401559 | 1.00 | SLC7A5 (0.67) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL7542588 | 0.97 | SLC7A5 (0.63) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL29076351 | 0.94 | SLC7A5 (0.59) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL2634732 | 0.94 | SLC7A5 (0.76) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL10945389 | 0.94 | SLC7A5 (0.76) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL208388 | 0.94 | SLC7A5 (0.76) | SLC7A5ALPIPKMPTGS1XIAP | |
| D-Phenylalanine SCHEMBL10775923 | 0.94 | SLC7A5 (0.76) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL31087886 | 0.94 | SLC7A5 (0.76) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 308 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117510828-A | Tri-arm polyethylene glycol derivative containing amino acid residue | 厦门赛诺邦格生物科技股份有限公司 | 2024-02-06 | — | — | CN | claimed |
| CN-117510829-A | Nitrogen-branched polyethylene glycol derivative containing amino acid residue | 厦门赛诺邦格生物科技股份有限公司 | 2024-02-06 | — | — | CN | claimed |
| WO-2024022237-A1 | THREE-ARM POLYETHYLENE GLYCOL DERIVATIVE CONTAINING AMINO ACID RESIDUES | 厦门赛诺邦格生物科技股份有限公司 | 2024-02-01 | — | — | WO | claimed |
| CN-112851928-B | Polyethylene glycol coupling drug, preparation method and application thereof | 重庆阿普格雷生物科技有限公司 | 2023-04-25 | — | — | CN | claimed |
| US-20230073036-A1 | POLYETHYLENE GLYCOL CONJUGATE DRUG, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Chongqing Upgra Biotechnology Co., Ltd. (CN) | 2023-03-09 | — | — | US | claimed |
| CN-109843333-B | Intermediate drug with synergistic anticancer activity and polyethylene glycol coupled synergistic anticancer drug, and preparation method and application thereof | 重庆阿普格雷生物科技有限公司 | 2023-02-03 | — | — | CN | claimed |
| CN-115317622-A | Preparation and application of anti-tumor polypeptide coupled drug | 青岛科技大学 | 2022-11-11 | — | — | CN | claimed |
| CN-110193086-B | LA-GFLG-DOX conjugate and preparation method and application thereof | 首都医科大学 | 2022-09-02 | — | — | CN | claimed |
| CN-110237255-B | Drug delivery system of targeting tumor cells and preparation method and application thereof | 首都医科大学 | 2021-10-22 | — | — | CN | claimed |
| WO-2021109351-A1 | POLYETHYLENE GLYCOL CONJUGATE DRUG, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 重庆阿普格雷生物科技有限公司 | 2021-06-10 | — | — | WO | claimed |
| WO-2008076771-A2 | COATINGS OF ACRYLAMIDE-BASED COPOLYMERS | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2008-06-26 | — | — | WO | claimed |
| US-20080146992-A1 | Coatings of acrylamide-based copolymers | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2008-06-19 | — | — | US | claimed |
| US-20050031575-A1 | Block copolymers | POLYTHERICS LIMITIED (GB) | 2005-02-10 | — | — | US | claimed |
| EP-1461369-A2 | BLOCK COPOLYMERS | Polytherics Limited (GB) | 2004-09-29 | — | — | EP | claimed |
| WO-2003059973-A2 | BLOCK COPOLYMERS | POLYTHERICS LIMITED (GB) | 2003-07-24 | — | — | WO | claimed |
| EP-0941123-B1 | NUCLEIC ACID COMPLEXED WITH CATIONIC POLYMER USEFUL FOR GENE THERAPY | HYBRID SYSTEMS LTD (GB) | 2002-06-12 | — | — | EP | claimed |
| US-6312727-B1 | SYNTHETIC POLYMER CARRIER VEHICLE FOR DELIVERY OF NUCLEIC ACID TO TARGET CELLS IN BIOLOGICAL SYSTEMS | HYBRID SYSTEMS LIMITED (GB) | 2001-11-06 | — | — | US | claimed |
| WO-2001036002-A1 | CONJUGATES OF HPMA COPOLYMER AND ELLIPTICIN | SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) | 2001-05-25 | — | — | WO | claimed |
| EP-0941123-A2 | DELIVERY OF NUCLEIC ACID MATERIAL TO TARGET CELLS IN BIOLOGICAL SYSTEMS | SCHACHT, Etienne Honoré (BE) | 1999-09-15 | — | — | EP | claimed |
| WO-1998019710-A2 | DELIVERY OF NUCLEIC ACID MATERIAL TO TARGET CELLS IN BIOLOGICAL SYSTEMS | SCHACHT ETIENNE HONORE (BE) | 1998-05-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230073036-A1 | POLYETHYLENE GLYCOL CONJUGATE DRUG, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SLC10A1, FAR1, THEM6 | SLC7A5 350/4885ALPI 763/4885PKM 1441/4885 |
| US-20050031575-A1 | Block copolymers | ACSL6, F12, ACSL1 | SLC7A5 257/4885ALPI 4238/4885PKM 939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.