THEM6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to THEM6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pharmacogenomic Evaluation of Antihypertensive Responses	PHASE4	COMPLETED
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety	PHASE2	COMPLETED
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
A Multicenter Study of NAP (AL-108) in Schizophrenia	PHASE2	COMPLETED
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis	nan	COMPLETED
Elucidating the Molecular and Biochemical Basis of the Human AhR-mutation Disease	nan	UNKNOWN
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
Proteogenomic Monitoring and Assessment of Liver Transplant Recipients	nan	RECRUITING
Chromosome 5Q Gene Variants and Asthma-Related Traits	nan	COMPLETED
Genetics and Epigenetics of Graves' Orbitopathy	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Identification and Characterization of Monogenic Diabetes	nan	COMPLETED
Monogenic Diabetes Misdiagnosed as Type 1	nan	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Microarray Analysis in Syndromic Obesity	nan	COMPLETED
Genomewide Search for Loci Underlying Metabolic Syndrome	nan	COMPLETED
The Role of TBC1D4 in Exercise- and Insulin-induced Glucose Metabolism in Human Skeletal Muscle	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles	nan	ACTIVE_NOT_RECRUITING
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Epidemiological and Genetic Studies of Body Mass Index	nan	COMPLETED
Natural History of Neuronal Ceroid Lipofuscinosis, Batten's CLN6 Diseae	nan	ACTIVE_NOT_RECRUITING
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
The Correlation Between Anemia of Chronic Diseases, Hepcidin and Vitamin D in IBD Patients	nan	UNKNOWN
Volumetrics and Proteomics in Shunted Normal Pressure Hydrocephalus	nan	UNKNOWN
New Strategies for Non-invasive Detection of Chronic Allograft Nephropathy	nan	COMPLETED
Family Blood Pressure Program - GENOA	nan	COMPLETED
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a THEM6 binder may also engage these)

Protein	Name	Similarity
Q80ZW2	—	0.992	Q80ZW2 →
Q5XIE1	—	0.991	Q5XIE1 →
A6H707	—	0.990	A6H707 →
G3MZR2	—	0.932	G3MZR2 →
Q32NY4	—	0.928	Q32NY4 →
Q8NE01	—	0.926	Q8NE01 →
O89109	—	0.926	O89109 →
P70295	—	0.925	P70295 →
Q9BQD7	—	0.923	Q9BQD7 →
Q99MR3	—	0.923	Q99MR3 →
GPAA1	GPI-anchor transamidase component GPAA1	0.922	landscape →
Q8NI29	—	0.922	Q8NI29 →
Q8IZ52	—	0.922	Q8IZ52 →
FUT7	Alpha-(1,3)-fucosyltransferase 7	0.921	landscape →
Q864R5	—	0.920	Q864R5 →
Q9BXP2	—	0.920	Q9BXP2 →
Q9P2E5	—	0.920	Q9P2E5 →
Q96EY9	—	0.920	Q96EY9 →
AUP1	Lipid droplet-regulating VLDL assembly factor AUP1	0.920	landscape →
Q8CC86	—	0.919	Q8CC86 →
Q501J2	—	0.919	Q501J2 →
Q9QYW1	—	0.919	Q9QYW1 →
Q6XQN1	—	0.919	Q6XQN1 →
PKN1	Serine/threonine-protein kinase N1	0.919	landscape →
LPCAT1	Lysophosphatidylcholine acyltransferase 1	0.919	landscape →
Q86VU5	—	0.918	Q86VU5 →
A1L134	—	0.918	A1L134 →
KCNN4	Intermediate conductance calcium-activated potassium channel protein 4	0.918	landscape →
Q59I47	—	0.917	Q59I47 →
Q99819	—	0.917	Q99819 →