Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.71 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.49 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684553 | 0.87 | KMT2A (0.64) | KMT2AGRM4HTTSMN1; SMN2LMNA | |
| SCHEMBL892318 | 0.83 | KMT2A (0.72) | KMT2AGRM4NAMPTTDP1ALDH1A1 | |
| SCHEMBL6604871 | 0.83 | KMT2A (1.00) | KMT2AGRM4NAMPTHTTLMNA | |
| SCHEMBL6605576 | 0.79 | HPGD (0.54) | KMT2AGRM4HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL7919011 | 0.78 | GRM4 (0.61) | KMT2AGRM4NAMPTSMN1; SMN2LMNA | |
| Ammonia Solution, Strong SCHEMBL20302197 | 0.78 | GRM4 (0.60) | KMT2AGRM4ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2438512 | 0.78 | NPC1 (0.57) | KMT2AGRM4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL23406006 | 0.77 | GRM4 (0.57) | KMT2AGRM4NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29743902 | 0.77 | GRM4 (0.60) | KMT2AGRM4NAMPTTDP1HTT | |
| SCHEMBL23406038 | 0.77 | GRM4 (0.60) | KMT2AGRM4NAMPTTDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922374-A | New catechol derivatives and the pharmaceutical composition containing it | 自体吞噬科学有限公司 | 2018-04-17 | — | — | CN | claimed |
| CN-1043127-A | Substituted thiazole and mycocide purposes thereof | MONSANTO CO (US) | 1990-06-20 | — | — | CN | claimed |
| CN-110218158-A | A method of photocatalytic synthesis is at amide compound in water phase | 福建医科大学 | 2019-09-10 | — | — | CN | disclosed |
| US-20190054068-A1 | Indole Amide Derivatives and Related Compounds for Use in the Treatment of Neurodegenerative Diseases | REMYND (BE) | 2019-02-21 | — | — | US | disclosed |
| EP-3397746-A1 | STABLE INOCULANT COMPOSITIONS AND METHODS FOR PRODUCING SAME | Novozymes BioAG A/S (DK) | 2018-11-07 | — | — | EP | disclosed |
| CN-107922374-A | New catechol derivatives and the pharmaceutical composition containing it | 自体吞噬科学有限公司 | 2018-04-17 | — | — | CN | disclosed |
| WO-2017116846-A1 | STABLE INOCULANT COMPOSITIONS AND METHODS FOR PRODUCING SAME | NOVOZYMES BIOAG A/S (DK) | 2017-07-06 | — | — | WO | disclosed |
| WO-2017015451-A1 | HEPATITIS B ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. (US) | 2017-01-26 | — | — | WO | disclosed |
| WO-2015050918-A1 | CO-FORMULATIONS OF BIFENTHRIN WITH ENCAPSULATED CROP PROTECTION AGENTS FOR USE WITH LIQUID FERTILIZERS | FMC CORPORATION (US) | 2015-04-09 | — | — | WO | disclosed |
| US-8618138-B2 | Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2013-12-31 | — | — | US | disclosed |
| US-20120083475-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-04-05 | — | — | US | disclosed |
| CN-101481359-A | Cyclic protein tyrosine kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2009-07-15 | — | — | CN | disclosed |
| EP-2021344-A1 | BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS | Bayer CropScience AG (DE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007115647-A1 | BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2007-10-18 | — | — | WO | disclosed |
| EP-1761502-A1 | N-PHENYLPYRAZOLE DERIVATIVES AS PESTICIDES | Merial Limited (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006000313-A1 | N-PHENYLPYRAZOLE DERIVATIVES AS PESTICIDES | MERIAL LTD. (US) | 2006-01-05 | — | — | WO | disclosed |
| CN-1348370-A | Cyclic protein tyrosine kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2002-05-08 | — | — | CN | disclosed |
| CN-1021010-C | SUBSTITUTED THIAZOLES COMPOSITION AND THEIR USE AS FUNGICIDES | MONSANTO CO (US) | 1993-06-02 | — | — | CN | disclosed |
| CN-1043127-A | Substituted thiazole and mycocide purposes thereof | MONSANTO CO (US) | 1990-06-20 | — | — | CN | disclosed |
| CN-1043127-A | Substituted thiazole and mycocide purposes thereof | MONSANTO CO (US) | 1990-06-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083475-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, MAPT, NLN | KMT2A 2251/4885GRM4 1570/4885NAMPT 536/4885 |
| US-20190054068-A1 | Indole Amide Derivatives and Related Compounds for Use in the Treatment of Neurodegenerative Diseases | SNCA, MAPT, NLN | KMT2A 2251/4885GRM4 1570/4885NAMPT 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.