Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 18/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8928439 | 0.92 | PTAFR (0.70) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9661361 | 0.91 | PTAFR (0.69) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| Bicarbonate SCHEMBL10510835 | 0.86 | PTAFR (0.72) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL10513136 | 0.86 | OPRK1 (0.68) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9654278 | 0.86 | OPRK1 (0.63) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9651412 | 0.85 | OPRK1 (0.62) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL11509934 | 0.85 | PTAFR (0.79) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL8928433 | 0.85 | PTAFR (0.79) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL9669268 | 0.83 | PTAFR (0.75) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| Etizolam SCHEMBL10869413 | 0.83 | OPRK1 (0.90) | PTAFROPRK1PDE4DCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776892-A1 | THIENYLAZOLE COMPOUND AND THIENOTRIAZOLODIAZEPINE COMPOUND | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-06-04 | — | — | EP | disclosed |
| EP-0230942-B1 | THIENO-1,4-DIAZEPINES | BOEHRINGER INGELHEIM KG (DE) | 1992-04-29 | — | — | EP | disclosed |
| US-4900729-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | BOEHRINGER INGELHEIM KG (DE) | 1990-02-13 | — | — | US | disclosed |