Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.62 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TTBK1 | Q5TCY1 | 5/20 | 0.41 |
| ▸ | TTBK2 | Q6IQ55 | 4/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830504 | 0.79 | JAK2 (0.42) | TRPA1JAK3 | |
| SCHEMBL4548928 | 0.78 | KDR (0.74) | TNNI3KKDRBRAFMAPK14MET | |
| SCHEMBL8929278 | 0.77 | TRPA1 (0.56) | TRPA1TNNI3KJAK3KDRBRAF | |
| SCHEMBL2882091 | 0.76 | TRPA1 (0.75) | TRPA1TNNI3KJAK3KDRBRAF | |
| SCHEMBL30564544 | 0.76 | TRPA1 (0.75) | TRPA1TNNI3KJAK3KDRBRAF | |
| SCHEMBL25793164 | 0.75 | TRPA1 (0.80) | TRPA1TNNI3KJAK3KDRBRAF | |
| SCHEMBL29837326 | 0.75 | TRPA1 (0.80) | TRPA1TNNI3KJAK3KDRBRAF | |
| SCHEMBL21593208 | 0.74 | NR1H2 (0.56) | TRPA1TNNI3KJAK3KDRBRAF | |
| SCHEMBL7830506 | 0.74 | PDPK1 (0.47) | BRAF | |
| SCHEMBL7821542 | 0.74 | NPC1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | claimed |
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | disclosed |