Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8930106 | 1.00 | MEN1 (0.46) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8547380 | 0.88 | GRIN2D (0.44) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8547375 | 0.88 | GRIN2D (0.44) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8930086 | 0.88 | ALOX15 (0.42) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8930091 | 0.88 | ALOX15 (0.42) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8547057 | 0.84 | GRIN2D (0.47) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8929677 | 0.84 | GRIN2D (0.47) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8543110 | 0.80 | EGFR (0.42) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8543113 | 0.80 | GRIN2D (0.43) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8547103 | 0.78 | GRIN2D (0.48) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656626-A | NERVOUS SYSTEM OR BRAIN DISORDERS; BENZ(B)AZEPINE | ZENECA LIMITED (GB) | 1997-08-12 | — | — | US | disclosed |
| WO-1994029275-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1994-12-22 | — | — | WO | disclosed |