Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.59 |
| ▸ | MEN1 | O00255 | 9/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29172833 | 0.89 | MEN1 (0.67) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL30823581 | 0.84 | MEN1 (0.62) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL8930572 | 0.82 | MEN1 (0.72) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL30440011 | 0.82 | MEN1 (0.72) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL30215701 | 0.81 | KMT2A (0.67) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL2388626 | 0.81 | KMT2A (0.67) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL20280484 | 0.81 | MAPT (0.70) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL367323 | 0.81 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL12960453 | 0.79 | KMT2A (0.58) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL12760847 | 0.79 | MAPT (0.70) | MAPTALDH1A1SMN1; SMN2TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188203-B2 | Intraocular lens formed from a polymer of an unsaturated aryl monoazo dye containing a 2-pyrazolin-5-one, dimedone (5,5-dimethyl-1,3-cyclohexanedione), acetoacetamide, malonamide, barbituric acid or 1,3-propanedione residue; yellow light absorbers; block ultraviolet and/or violet-blue light transmission | Abbott Medical Optics Inc. (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188203-B2 | Intraocular lens formed from a polymer of an unsaturated aryl monoazo dye containing a 2-pyrazolin-5-one, dimedone (5,5-dimethyl-1,3-cyclohexanedione), acetoacetamide, malonamide, barbituric acid or 1,3-propanedione residue; yellow light absorbers; block ultraviolet and/or violet-blue light transmission | Abbott Medical Optics Inc. (US) | 2012-05-29 | — | — | US | disclosed |
| EP-1815275-B1 | COPOLYMERIZABLE AZO COMPOUNDS AND ARTICLES CONTAINING THEM | ABBOTT MEDICAL OPTICS INC (US) | 2011-02-23 | — | — | EP | disclosed |
| EP-2261696-A1 | Copolymerizable azo compounds and articles containing them | Abbott Medical Optics Inc. (US) | 2010-12-15 | — | — | EP | disclosed |
| US-20080182957-A1 | Copolymerizable azo compounds and articles containing them | Johnson & Johnson Surgical Vision, Inc. | 2008-07-31 | — | — | US | disclosed |
| US-20080182957-A1 | Copolymerizable azo compounds and articles containing them | Johnson & Johnson Surgical Vision, Inc. | 2008-07-31 | — | — | US | disclosed |
| US-7326423-B2 | Copolymerizable azo compounds and articles containing them | ADVANCED MEDICAL OPTICS, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326423-B2 | Copolymerizable azo compounds and articles containing them | ADVANCED MEDICAL OPTICS, INC. (US) | 2008-02-05 | — | — | US | disclosed |