Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.65 |
| ▸ | MEN1 | O00255 | 9/20 | 0.65 |
| ▸ | XBP1 | P17861 | 1/20 | 0.64 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29172833 | 0.85 | MEN1 (0.67) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 | |
| SCHEMBL12760849 | 0.85 | MAPT (0.70) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 | |
| SCHEMBL12760847 | 0.85 | MAPT (0.70) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 | |
| SCHEMBL12760846 | 0.85 | MAPT (0.70) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 | |
| SCHEMBL2388626 | 0.82 | KMT2A (0.67) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 | |
| SCHEMBL30215701 | 0.82 | KMT2A (0.67) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 | |
| SCHEMBL305974 | 0.82 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 | |
| SCHEMBL305975 | 0.82 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 | |
| SCHEMBL21408444 | 0.82 | MEN1 (0.57) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 | |
| SCHEMBL1689493 | 0.82 | MAPT (0.70) | MAPTALDH1A1SMN1; SMN2NPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347001-B1 | AZOPHENOLS AS ERG ONCOGENE INHIBITORS | HENRY M JACKSON FOUND ADVANCEMENT MILITARY MEDICINE INC (US) | 2023-07-26 | — | — | EP | disclosed |
| US-10238639-B2 | Azophenols as ERG oncogene inhibitors | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180169074-A1 | Azophenols as ERG Oncogene Inhibitors | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169074-A1 | Azophenols as ERG Oncogene Inhibitors | ERG, ESR1, CBX2 | MAPT 4076/4885ALDH1A1 2314/4885SMN1; SMN2 4435/4885 |
| US-10238639-B2 | Azophenols as ERG oncogene inhibitors | ERG, ESR1, CBX2 | MAPT 4076/4885ALDH1A1 2314/4885SMN1; SMN2 4435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.