SCHEMBL8930699

SCHEMBL8930699

CCOC(=O)CSc1c2c(c(C(O)(c3c4c(c(SCC(=O)OC)c5c3OC(C)(C)O5)OC(C)(C)O4)c3c4c(c(SCC(=O)OC)c5c3OC(C)(C)O5)OC(C)(C)O4)c3c1OC(C)(C)O3)OC(C)(C)O2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.36
KMT2A Q03164 2/20 0.36
LMNA P02545 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
MEN1 O00255 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MAPT P10636 3/20 0.35
KDM4E B2RXH2 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CSNK2A2 P19784 1/20 0.35
CSNK2B P67870 1/20 0.35
CSNK2A1 P68400 1/20 0.35
GAA P10253 1/20 0.34
RAB9A P51151 1/20 0.34
POLB P06746 1/20 0.33
CCNB2 O95067 1/20 0.32
CCNE2 O96020 1/20 0.32
CDK1 P06493 1/20 0.32
CDK4 P11802 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8930709 0.95 ALDH1A1 (0.40) ALDH1A1KMT2ALMNASMN1; SMN2MEN1
SCHEMBL9268014 0.88 ALDH1A1 (0.35) ALDH1A1KMT2ALMNASMN1; SMN2MEN1
SCHEMBL8035909 0.84 ALDH1A1 (0.35) ALDH1A1KMT2ALMNASMN1; SMN2MEN1
SCHEMBL8048144 0.84 ALDH1A1 (0.35) ALDH1A1KMT2ALMNASMN1; SMN2MEN1
SCHEMBL8930659 0.79 ALDH1A1 (0.39) ALDH1A1KMT2ALMNASMN1; SMN2MEN1
SCHEMBL8930648 0.78 KDM4E (0.38) ALDH1A1KMT2ALMNASMN1; SMN2MEN1
SCHEMBL8930804 0.78
SCHEMBL8050700 0.75 ALDH1A1 (0.36) ALDH1A1KMT2ALMNASMN1; SMN2MEN1
SCHEMBL8210509 0.74 ALDH1A1 (0.34) ALDH1A1KMT2ALMNASMN1; SMN2MEN1
SCHEMBL8208364 0.74 ALDH1A1 (0.34) ALDH1A1KMT2ALMNASMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5599522-A CONTRAST ENHANCING AGENTS NYCOMED IMAGING AS (NO) 1997-02-04 US disclosed
EP-0515458-B1 TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI NYCOMED INNOVATION AB (SE) 1995-08-23 EP disclosed
EP-0515458-A1 TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI. HAFSLUND NYCOMED INNOVATION (SE) 1992-12-02 EP disclosed
WO-1991012024-A1 TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI HAFSLUND NYCOMED INNOVATION AB (SE) 1991-08-22 WO disclosed