Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.67 |
| ▸ | ABL1 | P00519 | 4/20 | 0.67 |
| ▸ | ABL2 | P42684 | 4/20 | 0.67 |
| ▸ | SRC | P12931 | 11/20 | 0.66 |
| ▸ | IGF1R | P08069 | 9/20 | 0.62 |
| ▸ | INSR | P06213 | 5/20 | 0.62 |
| ▸ | LYN | P07948 | 3/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.62 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.62 |
| ▸ | LATS1 | O95835 | 1/20 | 0.62 |
| ▸ | YES1 | P07947 | 1/20 | 0.62 |
| ▸ | HCK | P08631 | 1/20 | 0.62 |
| ▸ | FECH | P22830 | 1/20 | 0.62 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.62 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.62 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.62 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966762 | 0.88 | RIPK2 (0.62) | EGFRABL1ABL2SRCIGF1R | |
| SCHEMBL30180719 | 0.88 | RIPK2 (0.62) | EGFRABL1ABL2SRCIGF1R | |
| SCHEMBL30120763 | 0.86 | IGF1R (0.49) | EGFRABL1ABL2SRCIGF1R | |
| SCHEMBL24072895 | 0.86 | IGF1R (0.49) | EGFRABL1ABL2SRCIGF1R | |
| SCHEMBL23966752 | 0.86 | IGF1R (0.49) | EGFRABL1ABL2SRCIGF1R | |
| SCHEMBL18925735 | 0.86 | IGF1R (0.49) | EGFRABL1ABL2SRCIGF1R | |
| SCHEMBL30813404 | 0.82 | IGF1R (0.47) | EGFRABL1ABL2SRCIGF1R | |
| SCHEMBL27217870 | 0.82 | IGF1R (0.47) | EGFRABL1ABL2SRCIGF1R | |
| SCHEMBL13314317 | 0.81 | EGFR (0.74) | EGFRABL1ABL2SRCIGF1R | |
| SCHEMBL4819138 | 0.80 | IGF1R (0.79) | EGFRABL1ABL2SRCIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997028161-A1 | NOVEL PYRROLO[2,3-D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 1997-08-07 | — | — | WO | disclosed |