Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | DRD4 | P21917 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8931730 | 0.92 | MAPT (0.54) | DGAT1MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8931682 | 0.91 | DGAT1 (0.48) | DGAT1MAPTDRD4ALDH1A1KDM4E | |
| SCHEMBL8931698 | 0.91 | DGAT1 (0.56) | DGAT1MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8931744 | 0.90 | DGAT1 (0.48) | DGAT1MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8931641 | 0.90 | DGAT1 (0.44) | DGAT1MAPTDRD4CYP3A4DRD2 | |
| Hydrochloric Acid SCHEMBL8931711 | 0.89 | DGAT1 (0.51) | DGAT1MAPTDRD4ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8931688 | 0.89 | DGAT1 (0.47) | DGAT1MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8927419 | 0.89 | DGAT1 (0.47) | DGAT1MAPTDRD4ALDH1A1KDM4E | |
| SCHEMBL8931707 | 0.89 | MAPT (0.54) | DGAT1MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8931629 | 0.88 | DGAT1 (0.51) | DGAT1MAPTALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650411-A | BACTERICIDES FOR HELICOBACTER DISEASES AND BACTERIA RESISTANCE | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-07-22 | — | — | US | disclosed |
| EP-0684821-A1 | SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994018978-A1 | SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-09-01 | — | — | WO | disclosed |