SCHEMBL8932479

SCHEMBL8932479

COc1ccc(CSC(N)CCN)cc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.50
IDO1 P14902 5/20 0.47
SLC6A4 P31645 1/20 0.47
EPHX1 P07099 1/20 0.47
MAOB P27338 2/20 0.46
CYP1A2 P05177 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C19 P33261 1/20 0.45
ALDH1A1 P00352 2/20 0.44
TSHR P16473 2/20 0.42
AGXT P21549 2/20 0.42
APP P05067 1/20 0.41
BCHE P06276 1/20 0.41
ACHE P22303 1/20 0.41
TP53 P04637 1/20 0.41
CYP3A4 P08684 1/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7088679 0.79 SLC6A4 (0.58) TAAR1IDO1SLC6A4EPHX1CYP1A2
SCHEMBL5971492 0.78 SLC6A4 (0.53) IDO1SLC6A4EPHX1CYP1A2CYP2D6
SCHEMBL8932525 0.77 IDO1 (0.51) TAAR1IDO1SLC6A4EPHX1MAOB
SCHEMBL7881281 0.77 SLC6A4 (0.52) TAAR1IDO1SLC6A4EPHX1MAOB
SCHEMBL6571608 0.74 SLC6A4 (0.52) TAAR1IDO1SLC6A4EPHX1MAOB
SCHEMBL7604900 0.74 EPHX1 (0.45) IDO1EPHX1CYP2C19ALDH1A1ALOX15
SCHEMBL28785220 0.74 SLC6A4 (0.61) TAAR1IDO1SLC6A4MAOBCYP1A2
SCHEMBL10641646 0.73 MAOB (0.43) TAAR1IDO1SLC6A4EPHX1MAOB
SCHEMBL672238 0.72 TAAR1 (0.57) TAAR1IDO1SLC6A4MAOBALDH1A1
SCHEMBL7088751 0.71 IDO1 (0.45) TAAR1IDO1SLC6A4MAOBCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996026939-A1 CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-09-06 WO disclosed