Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TYMS | P04818 | 4/20 | 0.51 |
| ▸ | PARP1 | P09874 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30764972 | 0.83 | TNKS (0.46) | MAPK1TYMSALDH1A1TNKS2KDM4E | |
| SCHEMBL6124884 | 0.81 | TNKS2 (0.54) | TYMSALDH1A1TNKS2KDM4EMAPT | |
| SCHEMBL6124872 | 0.81 | ELANE (0.44) | MAPK1TYMSALDH1A1TNKS2KDM4E | |
| SCHEMBL8198913 | 0.78 | TNKS (0.42) | TYMSALDH1A1TNKS2KDM4ESMN1; SMN2 | |
| SCHEMBL6124881 | 0.77 | ELANE (0.44) | MAPK1TYMSALDH1A1TNKS2KDM4E | |
| SCHEMBL8191558 | 0.77 | ALDH1A1 (0.62) | MAPK1ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL7878783 | 0.74 | ELANE (0.43) | ALDH1A1TNKS2KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL2689332 | 0.71 | PDPK1 (0.50) | PARP1ALDH1A1TNKS2SMN1; SMN2NPC1 | |
| SCHEMBL22988563 | 0.71 | ELANE (0.43) | ALDH1A1KDM4ESMN1; SMN2NPC1MAPT | |
| SCHEMBL14043486 | 0.71 | RXFP1 (0.40) | MAPK1ALDH1A1TNKS2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |