Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.56 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NAT1 | P18440 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895510 | 1.00 | PTGS2 (0.56) | PTGS2HSD17B3PTGS1ALDH1A1POLB | |
| SCHEMBL7246589 | 0.81 | NAT1 (0.69) | PTGS2HSD17B3PTGS1ALDH1A1ALOX5 | |
| SCHEMBL7246592 | 0.81 | NAT1 (0.69) | PTGS2HSD17B3PTGS1ALDH1A1ALOX5 | |
| SCHEMBL8198993 | 0.81 | NAT1 (0.69) | PTGS2HSD17B3PTGS1ALDH1A1ALOX5 | |
| SCHEMBL7702501 | 0.80 | NAT1 (0.70) | PTGS2PTGS1ALDH1A1ALOX5KMT2A | |
| SCHEMBL7702499 | 0.80 | NAT1 (0.70) | PTGS2PTGS1ALDH1A1ALOX5KMT2A | |
| SCHEMBL8534268 | 0.78 | PTGS2 (0.55) | PTGS2PTGS1ALDH1A1ALOX5KMT2A | |
| SCHEMBL8534273 | 0.78 | PTGS2 (0.55) | PTGS2PTGS1ALDH1A1ALOX5KMT2A | |
| SCHEMBL8894620 | 0.76 | PTGS2 (0.51) | PTGS2PTGS1ALDH1A1ALOX5KMT2A | |
| SCHEMBL8933347 | 0.76 | PTGS2 (0.51) | PTGS2PTGS1ALDH1A1ALOX5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022772-A1 | METHOD FOR TREATING MULTIPLE SCLEROSIS | ELI LILLY AND COMPANY (US) | 1996-08-01 | — | — | WO | disclosed |
| EP-0722729-A2 | Aryl-substituted rhodanines for treating multiple sclerosis | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0391644-B1 | Aryl-substituted rhodanine derivatives | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5356917-A | Antiischemic, antiinflammatory, antiarthritic agents, treat-ment of dystrophic mammals | ELI LILLY AND COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5158966-A | Aryl-substituted rhodanine derivatives | THE UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-10-27 | — | — | US | disclosed |