SCHEMBL8933600

SCHEMBL8933600

COc1ccc([P@@](C)(=S)c2ccccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA4 P22748 1/20 0.52
LTA4H P09960 2/20 0.50
CYP1A2 P05177 2/20 0.47
CYP2C19 P33261 2/20 0.47
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
TRPA1 O75762 1/20 0.45
NPC1 O15118 4/20 0.44
RAB9A P51151 4/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
MAPT P10636 4/20 0.43
HTT P42858 3/20 0.43
ALDH1A1 P00352 3/20 0.43
PKM P14618 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28728579 0.91 CA1 (0.55) CA4LTA4HCA12CA1CA2
SCHEMBL7900827 0.82 ESR1 (0.46) CA4CA2SMN1; SMN2MAPTHTT
SCHEMBL7162911 0.81 ESR1 (0.57) CA4LTA4HCA12CA1CA2
SCHEMBL8933620 0.81 ESR1 (0.57) CA4LTA4HCA12CA1CA2
SCHEMBL14277866 0.78 CA1 (0.55) CA4LTA4HCA12CA1CA2
SCHEMBL3805335 0.77 CA12 (0.44) CYP1A2CA12CA1CA2CA7
SCHEMBL8837417 0.77 CA1 (0.61) CA4LTA4HCA12CA1CA2
SCHEMBL5619254 0.77 CA4 (0.54) CA4LTA4HCA12CA1CA2
SCHEMBL10253680 0.77 CA4 (0.54) CA4LTA4HCYP1A2CYP2C19CA12
SCHEMBL5619896 0.77 CA4 (0.54) CA4LTA4HCA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996024601-A1 COMPLEXES, PROCESSES FOR THEIR PREPARATION AND THEIR USE UNIVERSITY COLLEGE DUBLIN (IE) 1996-08-15 WO claimed
WO-1996024601-A1 COMPLEXES, PROCESSES FOR THEIR PREPARATION AND THEIR USE UNIVERSITY COLLEGE DUBLIN (IE) 1996-08-15 WO disclosed