Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.65 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876995 | 0.85 | ALOX5 (0.61) | ALOX5ACACBALDH1A1 | |
| SCHEMBL8880045 | 0.85 | ALOX5 (0.61) | ALOX5ACACBALDH1A1 | |
| SCHEMBL8879173 | 0.85 | ALOX5 (0.61) | ALOX5ACACBALDH1A1 | |
| SCHEMBL12420450 | 0.81 | ALOX5 (0.83) | ALOX5 | |
| SCHEMBL13140099 | 0.81 | ALOX5 (0.83) | ALOX5 | |
| SCHEMBL8590069 | 0.79 | ALOX5 (1.00) | ALOX5ACACB | |
| SCHEMBL1894729 | 0.79 | ALOX5 (0.60) | ALOX5ACACB | |
| SCHEMBL6438420 | 0.79 | ALOX5 (1.00) | ALOX5ACACB | |
| SCHEMBL1807930 | 0.79 | ALOX5 (1.00) | ALOX5ACACB | |
| SCHEMBL19460245 | 0.79 | ALOX5 (0.60) | ALOX5ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996032377-A1 | LIPOXYGENASE AND CYCLOOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-10-17 | — | — | WO | disclosed |
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5516789-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1996-05-14 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |