Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8957270 | 1.00 | EGFR (0.61) | EGFRMEN1KMT2AERBB2PTP4A3 | |
| SCHEMBL7805259 | 0.91 | EGFR (0.60) | EGFRMEN1KMT2AERBB2PTP4A3 | |
| SCHEMBL7805261 | 0.91 | EGFR (0.60) | EGFRMEN1KMT2AERBB2PTP4A3 | |
| SCHEMBL9472266 | 0.80 | EGFR (0.67) | EGFRMEN1KMT2AIGF1RGAA | |
| SCHEMBL9472275 | 0.80 | EGFR (0.67) | EGFRMEN1KMT2AIGF1RGAA | |
| SCHEMBL8991940 | 0.78 | GAA (0.40) | EGFRMEN1KMT2APTP4A3PPARG | |
| SCHEMBL8933490 | 0.78 | GAA (0.40) | EGFRMEN1KMT2APTP4A3PPARG | |
| SCHEMBL9471772 | 0.78 | EGFR (0.66) | EGFRMEN1KMT2AERBB2ALDH1A1 | |
| SCHEMBL29429743 | 0.76 | EGFR (1.00) | EGFRMEN1KMT2AERBB2IGF1R | |
| SCHEMBL8957287 | 0.74 | CYP1A2 (0.50) | MEN1KMT2AIGF1RGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8040897-A | — | — | None | — | — | JP | disclosed |
| JP-H0840897-A | PHARMACEUTICAL COMPOSITION FOR INHIBITING BONE LOSS | ELI LILLY & CO | 1996-02-13 | — | — | JP | disclosed |
| EP-0691129-A2 | Thiazolidone and pyrrolidinone compounds for inhibiting bone loss | ELI LILLY AND COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |