Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 9/20 | 0.53 |
| ▸ | PPARG | P37231 | 9/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3879629 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2PPARAPPARGTDP1HTT | |
| SCHEMBL8935703 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2PPARAPPARGTDP1 | |
| SCHEMBL8935705 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2PPARAPPARGTDP1 | |
| SCHEMBL29213724 | 0.85 | TDP1 (0.54) | SMN1; SMN2PPARATDP1HTTKDM4E | |
| SCHEMBL4650644 | 0.83 | KMT2A (0.62) | SMN1; SMN2PPARAPPARGHTTALDH1A1 | |
| SCHEMBL8935639 | 0.83 | KMT2A (0.62) | SMN1; SMN2PPARAPPARGHTTALDH1A1 | |
| SCHEMBL6664136 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2PPARAPPARGTSHR | |
| SCHEMBL17633012 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2PPARAPPARGTSHR | |
| SCHEMBL8935961 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2PPARAPPARGTSHR | |
| SCHEMBL5861928 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2PPARAPPARGTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |