Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.77 |
| ▸ | PPARA | Q07869 | 12/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935921 | 1.00 | PPARG (0.77) | PPARGPPARASMN1; SMN2PTPN7AKR1C3 | |
| SCHEMBL30559867 | 1.00 | PPARG (0.77) | PPARGPPARASMN1; SMN2PTPN7AKR1C3 | |
| SCHEMBL11094172 | 0.86 | PPARG (0.62) | PPARGPPARASMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL2222030 | 0.86 | SMN1; SMN2 (0.59) | PPARGPPARASMN1; SMN2PTPN7AKR1C3 | |
| SCHEMBL2223492 | 0.84 | SMN1; SMN2 (0.57) | PPARGPPARASMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL2224818 | 0.84 | SMN1; SMN2 (0.57) | PPARGPPARASMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL1565456 | 0.84 | PPARG (0.83) | PPARGPPARASMN1; SMN2PTPN7 | |
| SCHEMBL4651839 | 0.84 | SMN1; SMN2 (0.64) | PPARGPPARASMN1; SMN2ALDH1A1 | |
| SCHEMBL295888 | 0.84 | SMN1; SMN2 (0.64) | PPARGPPARASMN1; SMN2ALDH1A1 | |
| SCHEMBL8315325 | 0.83 | PPARG (0.69) | PPARGPPARAPTPN7MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1070487-C | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 2001-09-05 | — | — | CN | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| CN-1098099-A | The hexahydro naphthalene ester derivative, their preparation and their treatment are used | SANKYO CO (JP) | 1995-02-01 | — | — | CN | disclosed |