Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19913373 | 0.82 | HPGD (0.42) | HPGDGAATSHRNPSR1ALDH1A1 | |
| SCHEMBL22047383 | 0.82 | HPGD (0.42) | HPGDGAATSHRNPSR1ALDH1A1 | |
| SCHEMBL888750 | 0.76 | HPGD (0.45) | HPGDGAATSHRNPSR1ALDH1A1 | |
| SCHEMBL888758 | 0.76 | HPGD (0.45) | HPGDGAATSHRNPSR1ALDH1A1 | |
| SCHEMBL8086658 | 0.76 | HPGD (0.45) | HPGDGAATSHRNPSR1ALDH1A1 | |
| SCHEMBL28145524 | 0.74 | TDP1 (0.44) | HPGDGAATSHRNPSR1ALDH1A1 | |
| SCHEMBL5026802 | 0.73 | NOS2 (0.43) | HPGDGAATSHRNPSR1ALDH1A1 | |
| SCHEMBL353811 | 0.73 | — | — | |
| SCHEMBL7381082 | 0.73 | NOS2 (0.43) | HPGDGAATSHRNPSR1ALDH1A1 | |
| SCHEMBL9305499 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494906-A | TREATING METABOLIC BONE DISEASE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1996-02-27 | — | — | US | disclosed |
| US-5478955-A | Chemical intermediates | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1995-12-26 | — | — | US | disclosed |
| US-5397775-A | 26,27-dimethylene-1α,25-dihydroxyvitamin D2 and 26,27-dimethylene-24-epi-1α,25-dihydroxyvitamin D2 and methods for preparing same | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1995-03-14 | — | — | US | disclosed |