Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936133 | 0.77 | TP53 (0.54) | TP53SMN1; SMN2PARP1CA12CA9 | |
| SCHEMBL28780337 | 0.77 | GPR84 (0.50) | PARP1CA12CA9DAOALDH1A1 | |
| SCHEMBL8127333 | 0.76 | TP53 (0.66) | TP53SMN1; SMN2PARP1CA12CA9 | |
| SCHEMBL29410772 | 0.75 | TP53 (0.70) | TP53SMN1; SMN2PARP1CA12CA9 | |
| SCHEMBL2796184 | 0.75 | TP53 (0.70) | TP53SMN1; SMN2PARP1CA12CA9 | |
| SCHEMBL8936101 | 0.75 | TP53 (0.55) | TP53SMN1; SMN2PARP1CA12CA9 | |
| SCHEMBL8936103 | 0.75 | TP53 (0.51) | TP53SMN1; SMN2PARP1CA12CA9 | |
| SCHEMBL2797754 | 0.74 | TP53 (1.00) | TP53SMN1; SMN2PARP1CA9LMNA | |
| SCHEMBL29483390 | 0.73 | TP53 (0.66) | TP53SMN1; SMN2PARP1CA12CA9 | |
| SCHEMBL29340202 | 0.73 | TP53 (0.66) | TP53SMN1; SMN2PARP1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510338-A | ADMINISTERING TO A MAMMAL TO RELIEVE PAIN AND TO TREAT CONVULSIONS, CEREBRAL ISCHEMIC DAMAGE, AND EMESIS | GUILFORD PHARMACEUTICALS INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5342946-A | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors | GUILFORD PHARMACEUTICALS INC. (US) | 1994-08-30 | — | — | US | disclosed |