Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 15/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936887 | 1.00 | PTPN1 (0.37) | PTPN1TACR1PTPN2PTPN6PPARG | |
| Hydrochloric Acid SCHEMBL8936924 | 0.99 | PTPN1 (0.36) | PTPN1TACR1PTPN2PTPN6PPARG | |
| Hydrochloric Acid SCHEMBL8936936 | 0.99 | PTPN1 (0.36) | PTPN1TACR1PTPN2PTPN6PPARG | |
| SCHEMBL8936912 | 0.71 | TACR1 (0.43) | TACR1MLNRABCB11ADRB1ADORA3 | |
| SCHEMBL8936883 | 0.69 | TACR1 (0.60) | TACR1MLNRABCB11ADRB1ADORA3 | |
| SCHEMBL8936879 | 0.69 | TACR1 (0.61) | TACR1MLNRABCB11ADRB1ADORA3 | |
| SCHEMBL8507790 | 0.64 | TACR1 (0.49) | TACR1CYP2D6 | |
| SCHEMBL8936904 | 0.63 | TACR1 (0.63) | TACR1 | |
| SCHEMBL7704915 | 0.63 | TACR1 (0.61) | TACR1CHRM1 | |
| SCHEMBL8936871 | 0.63 | TACR1 (0.45) | TACR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494926-A | ANTIINFLAMMATORY AGENT, ANTIARTHRITIC AGENT; TREATING PAIN, HEADACHE | MERCK SHARP & DOHME LTD. (GB) | 1996-02-27 | — | — | US | claimed |
| WO-1993024465-A1 | 2/3-(HETEROCYCLIC ALKYL AMINO)-1-(SUBST.-PHENYL-METHOXY)-ETHANES/PROPANES AS TACHYKININ-RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-12-09 | — | — | WO | claimed |