SCHEMBL8936871

SCHEMBL8936871

CC(c1ccccc1OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)Cc1nc[nH]n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 19/20 0.45
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
TP53 P04637 1/20 0.35
CYP1A2 P05177 1/20 0.35
POLB P06746 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
MAPT P10636 1/20 0.35
CYP2C9 P11712 1/20 0.35
NFKB1 P19838 1/20 0.35
APEX1 P27695 1/20 0.35
CYP2C19 P33261 1/20 0.35
THPO P40225 1/20 0.35
BLM P54132 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CACNA1F O60840 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8936832 0.82 TACR1 (0.61) TACR1KDM4EMEN1KMT2A
SCHEMBL8936863 0.81 TACR1 (0.45) TACR1KDM4EMEN1KMT2A
SCHEMBL8936828 0.80 TACR1 (0.38) TACR1KDM4EMEN1KMT2AALDH1A1
SCHEMBL8936826 0.79 TACR1 (0.61) TACR1KDM4EMEN1KMT2A
SCHEMBL9599084 0.78 TACR1 (0.47) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8936931 0.76 TACR1 (0.40) TACR1
SCHEMBL8936896 0.74 TACR1 (0.67) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8936903 0.74 TACR1 (0.39) TACR1
SCHEMBL8936909 0.73 TACR1 (0.38) TACR1
SCHEMBL8936904 0.73 TACR1 (0.63) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5494926-A ANTIINFLAMMATORY AGENT, ANTIARTHRITIC AGENT; TREATING PAIN, HEADACHE MERCK SHARP & DOHME LTD. (GB) 1996-02-27 US claimed
WO-1993024465-A1 2/3-(HETEROCYCLIC ALKYL AMINO)-1-(SUBST.-PHENYL-METHOXY)-ETHANES/PROPANES AS TACHYKININ-RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 1993-12-09 WO claimed
US-5494926-A ANTIINFLAMMATORY AGENT, ANTIARTHRITIC AGENT; TREATING PAIN, HEADACHE MERCK SHARP & DOHME LTD. (GB) 1996-02-27 US disclosed
WO-1993024465-A1 2/3-(HETEROCYCLIC ALKYL AMINO)-1-(SUBST.-PHENYL-METHOXY)-ETHANES/PROPANES AS TACHYKININ-RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 1993-12-09 WO disclosed