Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937335 | 1.00 | ALDH1A1 (0.58) | ALDH1A1CYP1A2HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8937329 | 1.00 | ALDH1A1 (0.58) | ALDH1A1CYP1A2HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8937601 | 0.95 | HPGD (0.60) | ALDH1A1CYP1A2HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8937598 | 0.95 | HPGD (0.60) | ALDH1A1CYP1A2HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8937541 | 0.94 | ALDH1A1 (0.59) | ALDH1A1CYP1A2HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8937537 | 0.94 | ALDH1A1 (0.59) | ALDH1A1CYP1A2HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8937413 | 0.92 | ALDH1A1 (0.61) | ALDH1A1CYP1A2HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8937410 | 0.92 | ALDH1A1 (0.61) | ALDH1A1CYP1A2HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8937415 | 0.92 | ALDH1A1 (0.61) | ALDH1A1CYP1A2HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8937707 | 0.89 | ALDH1A1 (0.70) | ALDH1A1CYP1A2L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |