Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PDE4A | P27815 | 5/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | TPMT | P51580 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29622998 | 1.00 | ABCG2 (0.57) | ABCG2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL7695693 | 1.00 | ABCG2 (0.57) | ABCG2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL7695696 | 1.00 | ABCG2 (0.57) | ABCG2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL9333581 | 0.93 | PDE4A (0.52) | ABCG2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL8815881 | 0.93 | PDE4A (0.52) | ABCG2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL9367554 | 0.92 | CA12 (0.62) | ABCG2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL10386299 | 0.92 | LMNA (0.59) | ABCG2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL5962285 | 0.91 | CA12 (0.65) | ABCG2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL10387717 | 0.89 | MEN1 (0.56) | PKMPOLBHDAC1HDAC8HDAC6 | |
| SCHEMBL10387718 | 0.89 | MEN1 (0.56) | PKMPOLBHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304376-A | Acrylic acid morpholide compound dispersed in polymer having melting point below degradation temperature of polymer | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 1994-04-19 | — | — | US | claimed |
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0381290-B1 | Use of a fungicidal composition for the curative treatment of fungal diseases in plants | SHELL INT RESEARCH (NL) | 1995-05-03 | — | — | EP | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5304376-A | Acrylic acid morpholide compound dispersed in polymer having melting point below degradation temperature of polymer | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 1994-04-19 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0395446-A2 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | Sankyo Company Limited (JP) | 1990-10-31 | — | — | EP | disclosed |