Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GPR183 | P32249 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937691 | 1.00 | KMT2A (0.52) | KMT2ARXFP1ALDH1A1MAPTNPC1 | |
| SCHEMBL8937695 | 1.00 | KMT2A (0.52) | KMT2ARXFP1ALDH1A1MAPTNPC1 | |
| SCHEMBL8937490 | 0.85 | GPR183 (0.52) | ALDH1A1NPC1RAB9APOLBGPR183 | |
| SCHEMBL8937312 | 0.81 | GPR183 (0.44) | KMT2AALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8937307 | 0.81 | GPR183 (0.44) | KMT2AALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8937304 | 0.81 | GPR183 (0.44) | KMT2AALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8937500 | 0.80 | ALDH1A1 (0.64) | KMT2AALDH1A1POLBGPR183ABL1 | |
| SCHEMBL8937637 | 0.80 | ALDH1A1 (0.64) | KMT2AALDH1A1POLBGPR183ABL1 | |
| SCHEMBL8937498 | 0.80 | ALDH1A1 (0.64) | KMT2AALDH1A1POLBGPR183ABL1 | |
| SCHEMBL8937669 | 0.80 | ALDH1A1 (0.52) | KMT2AALDH1A1MAPTGPR183ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |