Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10384427 | 0.84 | ASAH1 (0.49) | ALDH1A1POLBMAPK1KDM4ETP53 | |
| SCHEMBL22116261 | 0.84 | ASAH1 (0.49) | ALDH1A1POLBMAPK1KDM4ETP53 | |
| SCHEMBL9831331 | 0.84 | ASAH1 (0.49) | ALDH1A1POLBMAPK1KDM4ETP53 | |
| SCHEMBL17766503 | 0.82 | ALDH1A1 (0.43) | ALDH1A1POLBMAPK1KDM4ETP53 | |
| SCHEMBL5161779 | 0.82 | ASAH1 (0.47) | ALDH1A1POLBMAPK1KDM4ETP53 | |
| SCHEMBL11389346 | 0.80 | ASAH1 (0.44) | ALDH1A1POLBMAPK1KDM4ETP53 | |
| SCHEMBL7991346 | 0.78 | TNF (0.48) | ALDH1A1POLBMAPK1KDM4ETP53 | |
| SCHEMBL7520939 | 0.77 | NR1H2 (0.40) | ALDH1A1LMNATDP1 | |
| SCHEMBL7051684 | 0.76 | ALDH1A1 (0.46) | ALDH1A1POLBMAPK1KDM4ETP53 | |
| SCHEMBL4627045 | 0.76 | ALDH1A1 (0.46) | ALDH1A1POLBMAPK1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635023-A4 | COVALENTLY CROSS-LINKED OLIGONUCLEOTIDES. | ISIS PHARMACEUTICALS INC (US) | 1996-03-20 | — | — | EP | disclosed |
| EP-0635023-A1 | COVALENTLY CROSS-LINKED OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1995-01-25 | — | — | EP | disclosed |
| WO-1993018052-A1 | COVALENTLY CROSS-LINKED OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1993-09-16 | — | — | WO | disclosed |