Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938151 | 1.00 | ALOX15 (0.57) | ALOX15KDM4EALDH1A1GAAADRB3 | |
| Hydrochloric Acid SCHEMBL8938117 | 0.99 | ALOX15 (0.59) | ALOX15KDM4EALDH1A1GAAADRB3 | |
| Hydrochloric Acid SCHEMBL8938120 | 0.99 | ALOX15 (0.59) | ALOX15KDM4EALDH1A1GAAADRB3 | |
| SCHEMBL9188713 | 0.90 | ALOX15 (0.71) | ALOX15KDM4EALDH1A1GAAADRB3 | |
| SCHEMBL9189156 | 0.90 | ALOX15 (0.71) | ALOX15KDM4EALDH1A1GAAADRB3 | |
| SCHEMBL9192393 | 0.89 | ALOX15 (0.58) | ALOX15KDM4EALDH1A1GAAADRB3 | |
| SCHEMBL9192385 | 0.89 | ALOX15 (0.58) | ALOX15KDM4EALDH1A1GAAADRB3 | |
| Hydrochloric Acid SCHEMBL9192057 | 0.88 | ALOX15 (0.60) | ALOX15KDM4EALDH1A1GAAADRB3 | |
| Hydrochloric Acid SCHEMBL9192053 | 0.88 | ALOX15 (0.60) | ALOX15KDM4EALDH1A1GAAADRB3 | |
| Hydrochloric Acid SCHEMBL9193286 | 0.86 | ALOX15 (0.62) | ALOX15KDM4EGAAADRB3ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516350-B1 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | claimed |
| EP-0516350-A2 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | claimed |
| US-5502078-A | Chemical compounds | ZENECA LIMITED (GB) | 1996-03-26 | — | — | US | disclosed |
| EP-0516350-B1 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | disclosed |
| EP-0516350-A2 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |