Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938186 | 0.84 | SLC6A2 (0.42) | CYP2D6CYP1A2CYP3A4CYP2C9LMNA | |
| SCHEMBL8938437 | 0.83 | SLC6A2 (0.49) | CYP2D6CYP1A2CYP3A4MAPTCHRM2 | |
| SCHEMBL7351368 | 0.83 | SLC6A2 (0.49) | CYP2D6CYP1A2CYP3A4MAPTCHRM2 | |
| SCHEMBL12064699 | 0.74 | DRD3 (0.51) | CYP2D6CYP1A2CYP3A4MAPTCHRM2 | |
| SCHEMBL12064952 | 0.74 | DRD3 (0.51) | CYP2D6CYP1A2CYP3A4MAPTCHRM2 | |
| SCHEMBL12064698 | 0.74 | DRD3 (0.51) | CYP2D6CYP1A2CYP3A4MAPTCHRM2 | |
| Hydrochloric Acid SCHEMBL4082542 | 0.73 | IDO1 (0.47) | CYP2D6CYP1A2CYP3A4CYP2C9LMNA | |
| SCHEMBL17955445 | 0.72 | HTR1A (0.50) | SLC6A2HTR1AHTR2CHTR2BCHRNB2 | |
| SCHEMBL3103033 | 0.72 | HTR1A (0.50) | SLC6A2HTR1AHTR2CHTR2BCHRNB2 | |
| SCHEMBL7352950 | 0.69 | CHRM1 (0.50) | CYP2D6CYP1A2CYP2C9CHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534626-A | SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES | PFIZER INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5410046-A | Selective muscarinic receptor antagonists | PFIZER INC. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5231104-A | Anticholinergic | PFIZER INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0350309-B1 | PIPERIDINE DERIVATIVES | Pfizer Limited (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089505-A | Anticholinergic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0350309-A1 | Piperidine derivatives | Pfizer Limited (GB) | 1990-01-10 | — | — | EP | disclosed |