Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | NMT1 | P30419 | 2/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938583 | 0.80 | HRH3 (0.38) | — | |
| SCHEMBL8938515 | 0.76 | ROCK1 (0.46) | HRH1 | |
| SCHEMBL1230464 | 0.72 | HRH1 (0.46) | MAP2K1HRH1SLC6A4HTR1ASLC6A2 | |
| SCHEMBL12316617 | 0.72 | MAP2K1 (0.40) | MAP2K1HRH1DDR1NMT1UTS2R | |
| SCHEMBL12316544 | 0.70 | MAP2K1 (0.41) | MAP2K1HRH1DDR1SLC6A4HTR1A | |
| SCHEMBL2553714 | 0.68 | MAP2K1 (0.46) | MAP2K1HRH1DDR1SLC6A4HTR1A | |
| Hydrochloric Acid SCHEMBL15391767 | 0.67 | MAP2K1 (0.45) | MAP2K1HRH1DDR1SLC6A4HTR1A | |
| SCHEMBL1231225 | 0.66 | HTR2C (0.48) | MAP2K1HRH1SLC6A4HTR1ASLC6A2 | |
| SCHEMBL5372606 | 0.65 | HTR2C (0.55) | SLC6A4HTR1ASLC6A2HTR6HTR2C | |
| SCHEMBL1782182 | 0.65 | HTR2C (0.55) | SLC6A4NMT1HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |