Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 7/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.51 |
| ▸ | HTR2A | P28223 | 5/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816009 | 1.00 | HTR2B (0.57) | HTR2BHTR7CHRM4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL8901730 | 0.98 | HTR2B (0.55) | HTR2BHTR7CHRM4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL8684136 | 0.98 | HTR2B (0.55) | HTR2BHTR7CHRM4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9413335 | 0.85 | HTR2B (0.58) | HTR2BHTR7CHRM4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7833621 | 0.83 | HTR2B (0.72) | HTR2BHTR7CHRM4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL8684071 | 0.82 | HTR2B (0.58) | HTR2BHTR7CHRM4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL8684280 | 0.82 | HTR2B (0.58) | HTR2BHTR7CHRM4HTR2AHTR2C | |
| SCHEMBL8771830 | 0.78 | HTR2B (0.66) | HTR2BHTR7CHRM4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7818685 | 0.78 | HTR2B (0.71) | HTR2BHTR7CHRM4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7808526 | 0.77 | HTR2B (0.68) | HTR2BHTR7CHRM4HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538981-A | 5-HYDROXYTRYPTAMINE RECEPTOR ANTAGONIST ACTIVITY | ELI LILLY AND COMPANY (US) | 1996-07-23 | — | — | US | claimed |
| EP-0620223-A2 | Tetrahydro-pyrido-indole | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | claimed |
| US-5538981-A | 5-HYDROXYTRYPTAMINE RECEPTOR ANTAGONIST ACTIVITY | ELI LILLY AND COMPANY (US) | 1996-07-23 | — | — | US | disclosed |
| US-5538980-A | CENTRAL NERVOUS SYSTEM | ELI LILLY AND COMPANY (US) | 1996-07-23 | — | — | US | disclosed |
| US-5488053-A | Tetrahydro-pyrido-indole | ELI LILLY AND COMPANY (US) | 1996-01-30 | — | — | US | disclosed |
| EP-0620223-A2 | Tetrahydro-pyrido-indole | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |
| US-5300645-A | Condensation of cycloalkyl-, phenyl- or naphthylpyrrole ethylamines with a 2-oxazolidinone to get antiserotonine agent | ELI LILLY AND COMPANY (US) | 1994-04-05 | — | — | US | disclosed |