Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 11/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939231 | 0.94 | HRH1 (0.42) | HRH3HTR2CHTR2BHRH1KCNH2 | |
| SCHEMBL8934714 | 0.83 | HRH3 (0.39) | HRH3 | |
| SCHEMBL8934704 | 0.78 | MAP2K1 (0.50) | ROCK1HRH1 | |
| SCHEMBL2337307 | 0.78 | KMO (0.41) | ROCK1SCD | |
| SCHEMBL2337304 | 0.78 | KMO (0.41) | ROCK1SCD | |
| SCHEMBL4608510 | 0.78 | KMO (0.41) | ROCK1 | |
| Hydrochloric Acid SCHEMBL2338809 | 0.78 | KMO (0.41) | ROCK1SCD | |
| SCHEMBL4961099 | 0.78 | KMO (0.41) | ROCK1SCD | |
| Hydrochloric Acid SCHEMBL2338812 | 0.78 | KMO (0.41) | ROCK1SCD | |
| SCHEMBL4961096 | 0.78 | KMO (0.41) | ROCK1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |