SCHEMBL8939711

SCHEMBL8939711

CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=N)C1(C(F)(F)F)C(F)(F)F

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 9/20 0.59
PGR P06401 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9412807 0.88 AR (0.67) ARPGR
SCHEMBL8939587 0.86 AR (0.64) ARPGR
SCHEMBL4023027 0.80 AR (0.74) ARPGR
SCHEMBL4026199 0.80 AR (0.78) ARPGR
SCHEMBL8939558 0.79 AR (0.77) ARPGR
SCHEMBL7760566 0.78 AR (0.66) ARPGR
SCHEMBL2221478 0.76 AR (0.78) ARPGR
SCHEMBL7762389 0.76 AR (0.64) ARPGR
SCHEMBL1715846 0.76 AR (0.64) ARPGR
SCHEMBL7759696 0.76 AR (0.67) ARPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5589497-A ANTIANDROGENS Uclaf, Roussel (FR) 1996-12-31 US disclosed
US-5556983-A ANTIANDROGENS ROUSSEL UCLAF (FR) 1996-09-17 US disclosed
US-5434176-A Antiandrogens ROUSSEL UCLAF (FR) 1995-07-18 US disclosed
EP-0578516-A1 Optionally substituted phenylimidazolidins, process for their preparation, their use as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1994-01-12 EP disclosed