Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 7/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941349 | 0.92 | LTB4R (0.59) | LTB4RCYSLTR2CYSLTR1LTB4R2CYP1A2 | |
| SCHEMBL8957156 | 0.91 | CYSLTR2 (0.55) | LTB4RCYSLTR2CYSLTR1CYP1A2MAPT | |
| SCHEMBL8941560 | 0.89 | CYSLTR2 (0.51) | LTB4RCYSLTR2CYSLTR1LTB4R2CYP1A2 | |
| SCHEMBL8941368 | 0.86 | LTB4R (0.66) | LTB4RCYSLTR2CYSLTR1LTB4R2CYP1A2 | |
| SCHEMBL8957186 | 0.84 | CYSLTR2 (0.65) | LTB4RCYSLTR2CYSLTR1CYP1A2MAPT | |
| SCHEMBL8941405 | 0.84 | SCN9A (0.48) | LTB4RCYSLTR2CYSLTR1LTB4R2CYP1A2 | |
| SCHEMBL8957215 | 0.81 | CYSLTR2 (0.56) | LTB4RCYSLTR2CYSLTR1CYP1A2MAPT | |
| SCHEMBL9192377 | 0.81 | CYSLTR2 (0.60) | LTB4RCYSLTR2CYSLTR1CYP1A2MAPT | |
| SCHEMBL8941387 | 0.80 | CYSLTR2 (0.59) | LTB4RCYSLTR2CYSLTR1LTB4R2CYP1A2 | |
| SCHEMBL8957143 | 0.77 | LTB4R (0.55) | LTB4RCYSLTR2CYSLTR1LTB4R2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532383-A | Leukotriene B4 antagonists | G. D. SEARLE & CO. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5516917-A | ANTIINFLAMMATORY AGENTS | G. D. SEARLE & CO. (US) | 1996-05-14 | — | — | US | disclosed |
| EP-0593478-B1 | LEUKOTRIENE B 4 ANTAGONISTS | SEARLE & CO (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5439937-A | Leukotriene B4 antagonists | G. D. SEARLE & CO. (US) | 1995-08-08 | — | — | US | disclosed |
| US-5310951-A | Benzopyran-2-propanoic acid derivatives; antiinflammatory agents | G.D. SEARLE & CO. (US) | 1994-05-10 | — | — | US | disclosed |
| EP-0593478-A1 | LEUKOTRIENE B 4? ANTAGONISTS. | SEARLE & CO (US) | 1994-04-27 | — | — | EP | disclosed |
| US-5124350-A | Antiinflammatory agent | G. D. SEARLE & CO. (US) | 1992-06-23 | — | — | US | disclosed |
| WO-1992000011-A2 | LEUKOTRIENE B4 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1992-01-09 | — | — | WO | disclosed |