Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 19/20 | 0.83 |
| ▸ | LTB4R2 | Q9NPC1 | 11/20 | 0.83 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941442 | 0.95 | LTB4R (0.76) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL8957138 | 0.93 | LTB4R (0.75) | LTB4RLTB4R2 | |
| SCHEMBL1447495 | 0.91 | LTB4R (1.00) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL29369941 | 0.91 | LTB4R (1.00) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL8941394 | 0.91 | LTB4R (0.69) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL29354842 | 0.91 | LTB4R (1.00) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL1890696 | 0.91 | LTB4R (1.00) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL5694677 | 0.88 | LTB4R (0.76) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL8941423 | 0.87 | LTB4R (0.90) | LTB4RLTB4R2 | |
| SCHEMBL8941433 | 0.86 | LTB4R (0.91) | LTB4RLTB4R2CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532383-A | Leukotriene B4 antagonists | G. D. SEARLE & CO. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5516917-A | ANTIINFLAMMATORY AGENTS | G. D. SEARLE & CO. (US) | 1996-05-14 | — | — | US | disclosed |
| WO-1995033742-A1 | LEUKOTRIENE B4 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1995-12-14 | — | — | WO | disclosed |
| EP-0593478-B1 | LEUKOTRIENE B 4 ANTAGONISTS | SEARLE & CO (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5310951-A | Benzopyran-2-propanoic acid derivatives; antiinflammatory agents | G.D. SEARLE & CO. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5124350-A | Antiinflammatory agent | G. D. SEARLE & CO. (US) | 1992-06-23 | — | — | US | disclosed |
| WO-1992000011-A2 | LEUKOTRIENE B4 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1992-01-09 | — | — | WO | disclosed |