Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | KDM5A | P29375 | 2/20 | 0.31 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.31 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.31 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.31 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.31 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346677 | 1.00 | KDM4E (0.31) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL8942533 | 0.88 | — | — | |
| SCHEMBL8349272 | 0.88 | — | — | |
| SCHEMBL8351202 | 0.79 | KDM4E (0.35) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL8346724 | 0.77 | KDM4E (0.31) | KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL8608681 | 0.77 | PTGS1 (0.47) | KDM4EMAPTPTGS1PTGS2 | |
| SCHEMBL8889035 | 0.77 | PTGS1 (0.47) | KDM4EMAPTPTGS1PTGS2 | |
| SCHEMBL8344078 | 0.74 | PGK1 (0.33) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL8942071 | 0.73 | KDM4E (0.33) | KDM4EALDH1A1 | |
| SCHEMBL23571483 | 0.72 | KDM5A (0.38) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | claimed |
| US-5482933-A | ANOXIA, ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-09 | — | — | US | disclosed |
| US-5480876-A | FROM ANOXIA OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-02 | — | — | US | disclosed |
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |