Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.60 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.60 |
| ▸ | AGT | P01019 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 5/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789482 | 0.87 | AGTR1 (0.61) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL8942681 | 0.87 | AGTR1 (0.60) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL14855469 | 0.85 | AGTR1 (0.60) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL14854911 | 0.83 | AGTR1 (0.60) | AGTR1AGTR2 | |
| SCHEMBL8942863 | 0.82 | AGTR1 (0.50) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL8789152 | 0.82 | AGT (0.58) | AGTR1AGTR2AGT | |
| SCHEMBL9851472 | 0.82 | AGTR1 (0.63) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL8942854 | 0.82 | AGTR1 (0.51) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL8942858 | 0.82 | AGTR1 (0.51) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL8943008 | 0.81 | AGTR1 (0.50) | AGTR1AGTR2AGTPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5521177-A | ANGIOTENSIN ANTAGONIST FOR CARDIOVASCULAR DISORDERS SUCH AS ISCHEMIA OR CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS COGNITIVE FUNCTIONS, DEPRESSION, ALZHEIMER'S DISEASE OR PARKINSON'S SYNDROME | DR. KARL THOMAE GMBH (DE) | 1996-05-28 | — | — | US | disclosed |
| EP-0591891-A2 | Benzimidazole derivatives as Angiotensin II antagonists | Dr. Karl Thomae GmbH (DE) | 1994-04-13 | — | — | EP | disclosed |