Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 17/20 | 0.65 |
| ▸ | AGTR2 | P50052 | 10/20 | 0.65 |
| ▸ | EDNRA | P25101 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942929 | 0.90 | AGTR1 (0.66) | AGTR1AGTR2PPARG | |
| SCHEMBL8943009 | 0.89 | AGTR1 (0.65) | AGTR1AGTR2PPARG | |
| SCHEMBL8942988 | 0.84 | AGTR1 (0.53) | AGTR1AGTR2EDNRA | |
| SCHEMBL8943178 | 0.82 | AGTR1 (0.74) | AGTR1AGTR2PPARG | |
| SCHEMBL8942636 | 0.82 | AGTR1 (0.73) | AGTR1AGTR2PPARG | |
| SCHEMBL8942892 | 0.81 | AGTR1 (0.68) | AGTR1AGTR2PPARG | |
| SCHEMBL8942887 | 0.81 | AGTR1 (0.68) | AGTR1AGTR2PPARG | |
| SCHEMBL8942716 | 0.80 | AGTR1 (0.60) | AGTR1AGTR2PPARG | |
| SCHEMBL4553370 | 0.80 | AGTR1 (0.65) | AGTR1AGTR2PPARG | |
| SCHEMBL8942968 | 0.80 | AGTR1 (0.66) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5521177-A | ANGIOTENSIN ANTAGONIST FOR CARDIOVASCULAR DISORDERS SUCH AS ISCHEMIA OR CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS COGNITIVE FUNCTIONS, DEPRESSION, ALZHEIMER'S DISEASE OR PARKINSON'S SYNDROME | DR. KARL THOMAE GMBH (DE) | 1996-05-28 | — | — | US | disclosed |