Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | IGF1R | P08069 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30547268 | 0.85 | RECQL (0.68) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL11626341 | 0.85 | RECQL (0.68) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL10532593 | 0.83 | RECQL (0.67) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL13875130 | 0.82 | RECQL (0.73) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL12781836 | 0.82 | RECQL (0.73) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL12304200 | 0.81 | DRD2 (0.66) | HTR1AALDH1A1KDM4ERECQLIGF1R | |
| SCHEMBL8442587 | 0.81 | IGF1R (0.81) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8483863 | 0.81 | RECQL (0.71) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8483868 | 0.81 | RECQL (0.71) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL7291084 | 0.81 | RECQL (0.71) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541326-A | PHARMACEUTICAL COMPOSITION USED TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-07-30 | — | — | US | disclosed |
| US-5420278-A | ω-(4-aryl or heteroarylpiperazine-1-yl)-2-aryl or aralkyl-propanoic or butanoic acids | JOHN WYETH & BROTHER, LIMITED (GB) | 1995-05-30 | — | — | US | disclosed |
| US-5382583-A | Hydroxytryptamine antagonists | JOHN WYETH & BROTHER, LIMITED (GB) | 1995-01-17 | — | — | US | disclosed |
| US-5364849-A | Treatment of anxiety | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-11-15 | — | — | US | disclosed |
| US-5340812-A | Antiserotonin. anxiolytic agents | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-08-23 | — | — | US | disclosed |
| EP-0395312-A2 | Piperazine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1990-10-31 | — | — | EP | disclosed |