Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.82 |
| ▸ | DNMT3B | Q9UBC3 | 3/20 | 0.82 |
| ▸ | PNMT | P11086 | 2/20 | 0.82 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.82 |
| ▸ | PRMT7 | Q9NVM4 | 2/20 | 0.79 |
| ▸ | AHCY | P23526 | 6/20 | 0.76 |
| ▸ | NADK | O95544 | 1/20 | 0.76 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.72 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.72 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.72 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.72 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.72 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.72 |
| ▸ | INMT | O95050 | 1/20 | 0.72 |
| ▸ | NSD2 | O96028 | 1/20 | 0.72 |
| ▸ | NNMT | P40261 | 1/20 | 0.72 |
| ▸ | HNMT | P50135 | 1/20 | 0.72 |
| ▸ | WDR5 | P61964 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8943754 | 1.00 | DOT1L (0.82) | DOT1LDNMT3BPNMTDNMT1PRMT7 | |
| SCHEMBL6902227 | 0.90 | DOT1L (0.84) | DOT1LDNMT3BPNMTDNMT1PRMT7 | |
| SCHEMBL5055464 | 0.90 | DOT1L (1.00) | DOT1LDNMT3BPNMTDNMT1PRMT7 | |
| SCHEMBL1490900 | 0.90 | DOT1L (0.84) | DOT1LDNMT3BPNMTDNMT1PRMT7 | |
| SCHEMBL1490901 | 0.90 | DOT1L (0.84) | DOT1LDNMT3BPNMTDNMT1PRMT7 | |
| SCHEMBL14174635 | 0.90 | DOT1L (1.00) | DOT1LDNMT3BPNMTDNMT1PRMT7 | |
| SCHEMBL8572440 | 0.90 | DOT1L (1.00) | DOT1LDNMT3BPNMTDNMT1PRMT7 | |
| SCHEMBL16272276 | 0.90 | DOT1L (1.00) | DOT1LDNMT3BPNMTDNMT1PRMT7 | |
| SCHEMBL8943575 | 0.89 | DOT1L (0.82) | DOT1LDNMT3BPNMTDNMT1PRMT7 | |
| SCHEMBL2829520 | 0.89 | DOT1L (0.82) | DOT1LDNMT3BPNMTDNMT1PRMT7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555352-A4 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH INC (US) | 1994-12-14 | — | — | EP | claimed |
| EP-0555352-A1 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH, INC. (US) | 1993-08-18 | — | — | EP | claimed |
| US-5180714-A | ADENOSINE COMPOUNDS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA | HEALTH RESEARCH, INC. (US) | 1993-01-19 | — | — | US | claimed |
| WO-1992007570-A1 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH, INC. (US) | 1992-05-14 | — | — | WO | claimed |
| US-5563125-A | 5'-deoxy-5'-(substituted)alkylthioribose compounds and their pharmaceutical compositions | HEALTH RESEARCH, INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5563125-A | 5'-deoxy-5'-(substituted)alkylthioribose compounds and their pharmaceutical compositions | HEALTH RESEARCH, INC. (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0555352-A4 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH INC (US) | 1994-12-14 | — | — | EP | disclosed |
| EP-0555352-A1 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH, INC. (US) | 1993-08-18 | — | — | EP | disclosed |
| EP-0555352-A1 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH, INC. (US) | 1993-08-18 | — | — | EP | disclosed |
| US-5180714-A | ADENOSINE COMPOUNDS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA | HEALTH RESEARCH, INC. (US) | 1993-01-19 | — | — | US | disclosed |
| US-5180714-A | ADENOSINE COMPOUNDS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA | HEALTH RESEARCH, INC. (US) | 1993-01-19 | — | — | US | disclosed |
| WO-1992007570-A1 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH, INC. (US) | 1992-05-14 | — | — | WO | disclosed |
| WO-1992007570-A1 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH, INC. (US) | 1992-05-14 | — | — | WO | disclosed |